"change" field in bindetect_results

[Amy Wang]

Hi, I might have missed this in the documentation somewhere, but what does the "cond1_cond2_change" field represent in the bindetect_results.txt table output by TOBIAS? Is this a subtraction of the mean score for condition 1 vs condition 2, a ratio, a log2 fold change, or something else?

[Mette Bentsen, PhD]

Hi @amwa ,

You can find more information in the supplementary information of the TOBIAS paper, here: https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-18035-1/MediaObjects/41467_2020_18035_MOESM1_ESM.pdf

Basically the change score (differential binding score) is an effect size between the observed changes between condition1 and condition2 vs. the background changes:

I hope that helps!