icbi-lab / nf-deseq2

A RNA-seq differential expression analysis pipeline downstream of nf-core/rnaseq.

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Add module for Progeny

grst opened this issue · comments

Progeny is a method for detecting enrichment of cancer pathways based on gene signatures

Input:

  • sample sheet
  • gene expression matrix

Output:

  • Plot
  • Table

I'm not sure if Progeny does proper statistical tests by group. If not, perform a simple statistical test, e.g. using a linear model.

Since it does not make sense to run Progeny on all datasets, this should be made optional (e.g. params.run_dorothea) and
be disabled by default.