Replicate https://doi.org/10.1038/nbt.2957

[Elton Law]

paper available here

Things that need to be implemented:

• Some sort of RNA seq rust struct to store arbitrary sequences
• Write the api calls to be able to query public databases for RNA seq data (and cache into s3) (use serde json)
  • ENCODE https://www.encodeproject.org/help/rest-api/
  • GDC https://docs.gdc.cancer.gov/API/Users_Guide/Search_and_Retrieval/
  • ICGC https://docs.icgc.org/portal/api/
• Write code to calculate measures
  • Avg measurement precision
  • Titration order consistency
  • Recovery of the expected A/B mixing ratio
  • differential expression
  • mutual information of sample titration