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dviraran / xCell

Cell types enrichment analysis

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Macrophage annotation

jiaren-zhang opened this issue · comments

commented

Hi I am a user of this great tool. One question is about Macrophage annotation. You have a cell type called "Macrophage", in addition to "Macrophage_M1" and "Macrophage M2", does this "Macrophage" mean M0 type?
Thank you.

commented

Hi,

Thank you!

The "macrophage" cell types is "general macrophages". The references are coming from several different sources. They are mostly non-activated macrophages, so you can say that this score will be most strongly associated with M0. However, I can't say that this signature can distinguish between M0 and M1 or M2.