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andrewhooker / PopED

Population Experimental Design (PopED) in R

Home Page:https://andrewhooker.github.io/PopED/

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Gradient function

mattfidler opened this issue · comments

commented

Hi @andrewhooker

Is there a place to provide a gradient to speed up the calculation?

Thanks in advance,

Matt

commented

Hi Matt,

There are a number of places a gradient can be supplied. Were you thinking for the FIM calculation, for improving gradient based search algorithms or something else?

Andy

commented

Thanks Andy,

Possibly for both. rxode2 calculates these for nlmixr2 focei and I thought they would be useful in both FIM calculation. I didn't see a hook so I didn't know if this was possible.

I was thinking of taking a nlmixr-style model and translating it to PopED, and was wondering if this would be useful and speed up the computation or increase the accuracy. This is currently mostly a development idea, but something I think may be useful.

Matt