Covariates per subject
rhocertara opened this issue · comments
Hello Andrew,
I am looking for a best way to include different covariates (e.g. weight, race, etc.). I have seen that one can add such in the "create_design" way but this seems to be good for some specifications per group. I would like to know if one can properly implement, for instance, an specific weight per subject for CL.
Thank you very much for your help in advance.
Roberto
Hi Roberto,
You can do this. The problem is that you slow down the computation of the FIM for the design, making optimization harder. Please see the attached file.
Best regards,
Andy
[covariate_distributions_2.pdf](https://github.com/andrewhooker/PopED/files/1990465/covariate_distributions_2.pdf)