Giters

OATML / EVE

Official repository for the paper "Large-scale clinical interpretation of genetic variants using evolutionary data and deep learning". Joint collaboration between the Marks lab and the OATML group.

Home Page:http://evemodel.org/

Geek Repo:Geek Repo

Github PK Tool:Github PK Tool

reproducing evolutionary indices with example scripts

AndreaGraf opened this issue · comments

commented

Hi,

I am trying to reproduce the results from your publication and evemodel.org. For the PTEN example this works well, but for the other proteins for which there is data in the repo (e.g. P53_HUMAN) the distribution of evolutionary indices is always shifted (or somewhat squashed) to lower values, compared to the distributions shown in the , like in the example below. Do you use the same default parameters and scripts for all example proteins ? And if not which should be tuned/changed from the PTEN example?

histogram_random_samples_next_P53_HUMAN

commented

Dear Andrea,
Apologies for the delayed response. Yes, we use the same default parameters for all proteins. Have you been able to reproduce the results since?
Kind regards,
Pascal

commented

Closing the issue now but feel free to re-open if needed.