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KChen-lab / MEDALT

Inference of Minimal Event Distance Aneuploidy Lineage Tree based on single cell copy number profile

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Multiple Samples

talban14 opened this issue · comments

commented

Thank you for the development of this very nice tool. I have a general question about how to run this on multiple samples to identify commonly amplified or deleted genes that drive tumor clone expansion as you demonstrated in your manuscript.

Do you just run it on every sample individually and then look at the overlap of significant genes? or do you combine all of the copy number analyses into one file and run it once?

Thank you,
Tyler