What does it mean if a cell is undiff in its cell type annotation?
njbernstein opened this issue · comments
Does that mean it is an undefined progenitor?
Yes, "undiff" just means that the cell wasn't confidently assigned to a
specific committed cell type. However the "undiff" cells comprise a
broad range of differentiation states, from putative HSCs to cells that are
well on their way toward a specific lineage and are already turning on
specific marker genes. In other words, it would be inaccurate to say that
they are "undifferentiated" in a formal biological sense.
…On Thu, Nov 18, 2021 at 6:19 PM njbernstein ***@***.***> wrote:
Does that mean it is an undefined progenitor?
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